Thales Alenia Space is a major contributor to the International Space Station (ISS), responsible for over half of its pressurized volume, and played a major role on the ATV (Automated Transfer Vehicle) cargo vessels for ESA and on NASA's Cygnus program, which will also bring supplies to the ISS.

Thales Alenia Space has leveraged its unrivaled expertise in orbital infrastructures and space transport to meet many challenges, including the IXV, a huge success that paves the way to future European reentry missions, and the pressurized compartment on SOAR (Sub-Orbital Aircraft Reusable), which will carry both scientific experiments and astronauts. Thales Alenia Space will also be a leading contributor to the Orion Multi-Purpose Crew Vehicle (MPCV) being developed by NASA.